Conformational analysis of the frog skin peptide, plasticin-L1, and its effects on production of proinflammatory cytokines by macrophages

MA Scorciapino, G Manzo, AC Rinaldi, R Sanna… - Biochemistry, 2013 - ACS Publications
Analysis of the structural properties of plasticin-L1 provided in this study has revealed a marked
affinity of the peptidePlasticin-L1 is not sufficiently soluble in water, methanol, TFE/water…

[PDF][PDF] Conformational Analysis of the Frog Skin Peptide, Plasticin-L1 and its Effects on the Production of Proinflammatory Cytokines by Macrophages

AC Rinaldi, G Manzo, R Sanna, M Casu, JM Pantic… - Biophysical …, 2014 - cell.com
cytokine IL-10 were not significant. These findings suggest that plasticin-L1 may play an …
role in vivo by stimulating cytokine production from frog skin macrophages in response to …

Immunomodulatory, insulinotropic, and cytotoxic activities of phylloseptins and plasticin‐TR from the Trinidanian leaf frog Phyllomedusa trinitatis

J Pantic, L Guilhaudis, V Musale… - Journal of Peptide …, 2019 - Wiley Online Library
… the effects of peptides that stimulate macrophages and other … In contrast to plasticin-L1,
plasticin-TR adopts a conformationPlasticin-L1 and all phylloseptin peptides stimulated release …

Conformational analysis and in vitro immunomodulatory and insulinotropic properties of the frog skin host-defense peptide rhinophrynin-27 and selected analogs

MA Scorciapino, P Carta, J Pantic, ML Lukic, A Lukic… - Biochimie, 2019 - Elsevier
… ) inhibited production of the pro-inflammatory cytokines TNF-… the production of IL-10 by mouse
peritoneal macrophages and … (Alytidae) [31] and plasticin-L1 from Leptodactylus laticeps (…

Potential therapeutic applications of multifunctional host-defense peptides from frog skin as anti-cancer, anti-viral, immunomodulatory, and anti-diabetic agents

JM Conlon, M Mechkarska, ML Lukic, PR Flatt - Peptides, 2014 - Elsevier
… stimulates production of the pro-inflammatory cytokines TNF… macrophages from C57BL/6
mice, the effect is significant only for unstimulated cells. Plasticin-L1 has no effect on production

The potential of frog skin-derived peptides for development into therapeutically-valuable immunomodulatory agents

JM Pantic, IP Jovanovic, GD Radosavljevic… - Molecules, 2017 - mdpi.com
… With a few exceptions, they lack a stable conformation in aqueous solutions, but adopt an …
Plasticin-L1 increased the production of IL-6 by macrophages in the presence or absence of …

Peptidomic analysis of the host-defense peptides in skin secretions of the Trinidadian leaf frog Phyllomedusa trinitatis (Phyllomedusidae)

M Mechkarska, L Coquet, J Leprince… - … and Physiology Part D …, 2018 - Elsevier
… are a group of conformationally flexible peptides, rich in … , plasticin-L1 a neutral non-cytotoxic
plasticin-related peptide … ) and increased the production of the proinflammatory cytokines IL-…

Conformational analysis and cytotoxic activities of the frog skin host-defense peptide, hymenochirin-1Pa

I Serra, MA Scorciapino, G Manzo, M Casu, AC Rinaldi… - Peptides, 2014 - Elsevier
… of host-defense peptides (magainin, peptide glycine-leucine-… fragment) identified in skin
secretions of Xenopus laevis and … study was to perform a first analysis of the conformation of a …

Purification, conformational analysis and cytotoxic activities of host-defense peptides from the Tungara frog Engystomops pustulosus (Leptodactylidae; Leiuperinae)

JM Conlon, L Guilhaudis, S Attoub, L Coquet… - Amino Acids, 2023 - Springer
Plasticin-L1 from L. laticeps lacks antimicrobial activity but … stimulating production of the
proinflammatory cytokines from … rugulosus with murine peritoneal macrophages and human …

In vivo administration of the frog skin peptide frenatin 2.1 S induces immunostimulatory phenotypes of mouse mononuclear cells

JM Pantic, GD Radosavljevic, IP Jovanovic… - Peptides, 2015 - Elsevier
… Antimicrobial peptides derived from frog skin display both … by in vitro cytokine production by
macrophages. Frenatin 2.1S, … vitro production of innate immunity pro-inflammatory cytokines